Lucas Moreno Selected Research

1- cyclopropyl- 3- (3- (5- morpholin- 4- ylmethyl- 1H- benzoimidazol- 2- yl)- 1H- pyrazol- 4- yl)urea

1/2015

A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study.

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Lucas Moreno Research Topics

Disease

38	Neoplasms (Cancer) 05/2024 - 01/2011
27	Neuroblastoma 01/2024 - 01/2011
5	Glioma (Gliomas) 01/2017 - 08/2010
4	Neoplasm Metastasis (Metastasis) 04/2024 - 01/2021
4	Rhabdomyosarcoma 10/2022 - 01/2020
3	Ependymoma 07/2020 - 07/2010
2	Leukemia 04/2024 - 11/2016
2	Medulloblastoma 08/2023 - 01/2011
2	Central Nervous System Neoplasms 08/2023 - 01/2023
2	Sarcoma (Soft Tissue Sarcoma) 01/2023 - 01/2014
2	Breast Neoplasms (Breast Cancer) 10/2022 - 01/2018
2	Cytokine Release Syndrome 08/2020 - 08/2020
1	Lymphoma (Lymphomas) 04/2024
1	Diffuse Intrinsic Pontine Glioma 08/2023
1	Brain Neoplasms (Brain Tumor) 08/2023
1	Ganglioneuroblastoma 11/2022
1	Bone Diseases (Bone Disease) 11/2022
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 12/2021
1	Disease Progression 01/2021
1	COVID-19 12/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 07/2020
1	Ewing Sarcoma (Sarcoma, Ewing) 01/2020
1	Hemorrhage 01/2019
1	Long Term Adverse Effects 07/2013
1	Familial ependymoma 01/2013
1	Hyperbilirubinemia 01/2012
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2012
1	Asphyxia (Suffocation) 01/2011
1	Respiratory Acidosis 01/2011

Drug/Important Bio-Agent (IBA)

8	Biomarkers (Surrogate Marker)IBA 05/2024 - 04/2016
4	Proteins (Proteins, Gene)FDA Link 04/2024 - 04/2016
3	Temozolomide (Temodar)FDA LinkGeneric 01/2024 - 11/2011
2	Topotecan (Hycamtin)FDA LinkGeneric 01/2024 - 01/2017
2	dipinacoline glutamateIBA 08/2023 - 01/2016
2	Histone Deacetylase InhibitorsIBA 01/2023 - 07/2020
2	IntegrinsIBA 10/2022 - 01/2022
2	Biological FactorsIBA 01/2021 - 10/2016
2	tocilizumab (atlizumab)FDA Link 08/2020 - 08/2020
2	130-nm albumin-bound paclitaxelIBA 01/2020 - 01/2018
2	Aurora Kinase AIBA 01/2020 - 01/2015
2	Antineoplastic Agents (Antineoplastics)IBA 11/2017 - 01/2011
2	Aurora KinasesIBA 01/2017 - 01/2015
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2024
1	Angiogenesis InhibitorsIBA 01/2024
1	Bevacizumab (Avastin)FDA Link 01/2024
1	LigandsIBA 01/2023
1	talimogene laherparepvecIBA 01/2023
1	3-Iodobenzylguanidine (Iobenguane)IBA 11/2022
1	Iodine-123IBA 11/2022
1	Peptides (Polypeptides)IBA 10/2022
1	ADAM ProteinsIBA 10/2022
1	integrin alpha9IBA 10/2022
1	ChromatinIBA 01/2022
1	Adenosine Triphosphatases (ATPase)IBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Cadherins (E-Cadherin)IBA 01/2022
1	Anaplastic Lymphoma KinaseIBA 12/2021
1	ceritinibIBA 12/2021
1	CateninsIBA 11/2021
1	WAY-262611IBA 11/2021
1	Messenger RNA (mRNA)IBA 09/2021
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	NucleotidesIBA 07/2020
1	Chimeric Antigen ReceptorsIBA 07/2020
1	vistusertibIBA 01/2020
1	MLN 8237IBA 01/2020
1	ABTL0812IBA 01/2020
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2019
1	cediranib (AZD2171)IBA 01/2019
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2017
1	Vincristine (Oncovin)FDA LinkGeneric 01/2017
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2017
1	Checkpoint Kinase 1IBA 01/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017
1	Oncogene Proteins (Oncogene Protein)IBA 04/2016
1	N-Myc Proto-Oncogene ProteinIBA 04/2016
1	1- cyclopropyl- 3- (3- (5- morpholin- 4- ylmethyl- 1H- benzoimidazol- 2- yl)- 1H- pyrazol- 4- yl)ureaIBA 01/2015
1	ImidazolinesIBA 01/2014
1	Melphalan (Alkeran)FDA LinkGeneric 07/2013
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2013
1	EndoglinIBA 01/2013
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2012
1	Alanine Transaminase (SGPT)IBA 01/2012
1	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2012
1	Clofarabine (Clolar)FDA Link 01/2012
1	Sodium Bicarbonate (Baking Soda)FDA LinkGeneric 01/2011

Therapy/Procedure

29	Therapeutics 05/2024 - 01/2011
14	Investigational Therapies (Experimental Therapy) 05/2024 - 01/2015
7	Immunotherapy 01/2023 - 01/2013
4	Drug Therapy (Chemotherapy) 01/2024 - 08/2010
3	Combined Modality Therapy 01/2022 - 07/2010
3	Precision Medicine 01/2020 - 01/2019
3	Induction Chemotherapy 01/2019 - 07/2013
1	Off-Label Use 04/2024
1	Palliative Care (Palliative Therapy) 08/2023
1	Oral Administration 01/2020
1	Injections 01/2020
1	Biological Therapy 01/2015